The Anti-CD11b antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD11b, CD11b / CD18, CD11b/CD18, integrin alpha M, ITGAM, Ly-40, and MAC1. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-CD11b antibody has been validated for the following applications: Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Integrin alpha-M(ITGAM) detection. Tested with WB in Human, Mouse, Rat.
Background: ITGAM(Integrin Alpha-M), also called CD11B or Mo1 ALPHA SUBUNIT(MO1A), is one protein subunit that forms the heterodimeric integrin alpha-M beta-2(alphaMbeta2) molecule. A major surface antigen family on human leukocytes includes complement receptor type 3(CR3A; also called ITGAM, Mac1, or Mo1), lymphocyte function-associated(LFA) antigen type 1(ITGAL), and p150, 95(ITGAX). By in situ hybridization, Corbi et al.(1988) demonstrated that the genes encoding the alpha subunits of LFA1(ITGAL), Mac1, and p150, 95(ITGAX), all of which are involved in leukocyte adhesion, constitute a cluster on 16p13.1-p11. Callen et al.(1991) narrowed the assignment to 16p11.2. Inflammation plays an essential role in the initiation and progression of atherosclerosis. Simon et al.(2000) presented evidence that it also has a role in vascular repair after mechanical arterial injury(i.e., percutaneous transluminal coronary angioplasty, or PTCA)